TY - JOUR T1 - 344 Comparison of clinical pathological and survival outcomes between serous and non-serous ovarian cancer JF - International Journal of Gynecologic Cancer JO - Int J Gynecol Cancer SP - A141 LP - A141 DO - 10.1136/ijgc-2020-IGCS.296 VL - 30 IS - Suppl 3 AU - H Mansouri AU - I Zemni AU - O Jaidane AU - M Chemlali AU - J Ben Hassouna AU - M Hechiche AU - R Chargui AU - K Ben Rahal Y1 - 2020/11/01 UR - http://ijgc.bmj.com/content/30/Suppl_3/A141.1.abstract N2 - Objectives To compare the clinical-pathological features and survival outcomes of women with serous and non-serous epithelial ovarian cancer.Methods Retrospective study of 151 patients staged surgically in Salah Azaiez Tunisian cancer center, between 2000 and 2010.Results We performed primary debulking surgery in 128 patients (84.8%) and 23 patients (15.2%) underwent and interval debulking surgery.Maximal cytoreduction (R0) was achieved in 67 of patients (44.4%),39 patients had a residual disease ≤1 cm (25.8%) and 45 patients had a residual disease >1 cm (28.8%).Lymphadenectomy was performed in 57% of cases.The histological type was clearly established for all women:109 cases of serous carcinomas (72.2%) and 71 non-serous tumors (14 endometrioid,12 mucinous,7 clear cell carcinomas,2 malignant Brenner tumors,6 undifferentiated and one case of seromucinous carcinoma).The comparison of serous (SEOC) to non-serous tumor types (NSEOC) by univariate analysis showed that SEOC were associated to higher serum level of CA 125 exceeding 1000UI/ml (47.7% vs 19%,p=0.001), higher quantity of ascites exceeding 1 litre (40.4% vs 21.4%,p=0.029) with more frequent cacinomatosis in the upper abdomen (48.6% vs 21.4%,p=0.002) and more residual disease R1/R2 (65.1% vs 31%,p<0.0001),bilateral tumors (74.1% vs 45.2%,p=0.001),advanced FIGO stage III-IV (88.1% vs 50%,p<0.0001),pelvic lymph metastasis (LNM) (11.7% vs 4.2%) as well as paraaortic LNM (16.7% vs 8.3%,p=0.012),higher LN ratio (12.57±21.96 vs1.77±5.62,p=0.01) and lymphovascular invasion (43.1% vs 9.5%,p<0.0001). NSEOC were associated to higher rates of 5-years overall survival (31.3% vs 54.2%,p=0.006) and recurrence free survival (31.8% vs 64.6%,p=0.002).Conclusion The management of EOC should take into account differences between histological subtypes. ER -