@article {NasioudisA47, author = {D Nasioudis and N Latif and E Ko and AF Haggerty and L Cory and MA Morgan and RL Giuntoli}, title = {96 Adjuvant treatment for adenosarcoma confined to the uterus provides no survival benefit}, volume = {30}, number = {Suppl 3}, pages = {A47--A48}, year = {2020}, doi = {10.1136/ijgc-2020-IGCS.87}, publisher = {BMJ Specialist Journals}, abstract = {Introduction Aim of the present study was to investigate patterns of use and outcomes of adjuvant treatment for patients with stage I adenosarcoma.Methods Patients diagnosed between 2004{\textendash}2015 with stage I adenosarcoma without a history of another tumor who underwent hysterectomy with lymphadenectomy and had at least one month of follow-up were drawn from the National Cancer Database. Patients who received adjuvant chemotherapy (CT) and/or radiotherapy (RT) defined as treatment within 6 months from surgery were identified. Overall survival (OS) was evaluated after generation of Kaplan-Meier curves and compared with the log-rank test. A Cox model was constructed to control for confounders.Results Among 735 patients with stage I adenosarcoma, 186 (25.3\%) received adjuvant treatment; 61.3\% RT only, 26.9\% CT only and 11.8\% both RT and CT. Rate of adjuvant treatment was 14.1\% for patients with stage IA compared to 35.8\% and 53.3\% for those with stage IB and IC, p\<0.001. Age, race, insurance, type of treatment facility and co-morbidities did not impact rate of adjuvant treatment administration, p\>0.05. Five year OS rate for patients who did not receive adjuvant treatment was 79.9\% compared to 63.4\%, 68.8\% and 74.1\% for those who received RT only, CT only and both CT and RT, p=0.002. After controlling for substage, patient age, insurance status and co-morbidities, administration of adjuvant treatment was not associated with a survival benefit (HR: 1.29, 95\% CI: 0.92, 1.58)Conclusions There is no clear benefit in the use of adjuvant treatment for patients with early stage adenosarcoma.}, issn = {1048-891X}, URL = {https://ijgc.bmj.com/content/30/Suppl_3/A47.3}, eprint = {https://ijgc.bmj.com/content/30/Suppl_3/A47.3.full.pdf}, journal = {International Journal of Gynecologic Cancer} }