RT Journal Article
SR Electronic
T1 342 Comparative assessment of survival rate in endometrial cancer intermediate risk
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP A139
OP A139
DO 10.1136/ijgc-2020-IGCS.294
VO 30
IS Suppl 3
A1 Mavrichev, S
YR 2020
UL http://ijgc.bmj.com/content/30/Suppl_3/A139.2.abstract
AB Background To evaluate the long-term results of surgical (ST) and combined treatment (CT) techniques for endometrial cancer (EC) of intermediate risk in a prospective randomized study.Methods 117 patients with an intermediate risk of EC received treatment at N.N. National cancer centre of Belarus. Patients were randomized for 3Cgroups.The first group - patients who underwent ST (simple hysterectomy with bilateral salpingo-oophorectomy (H-BSO) and pelvic lymphadenectomy).The second group - patients who underwent ST (the same volume of operation) with preoperative brachytherapy (PBT).The third group - patients who underwent ST (the same level of operation) with adjuvant endovaginal brachytherapy (EBT).Result We evaluate 5-year overall (OS), cancer-specified (CSS) and disease-free (DSF) survival rate in entire groups. In each group, OS, CSS and DFS survival rate was 87.8% (95% CI 80.7–93.3%), 91.4% (95% CI 84.8–95.8%) and 86.1% (95% CI 78.7–91.9%), respectively. Between all three groups, we don’t find any statistically significant differences in terms of OS, CSS, and DFS.Between ST and CT statistically significant differences in OS parameters (p=0.568), CSS (p=0.483) and DFS (p=0.846) also weren’t obtained. There weren’t statistically significant differences between the endometrioid carcinoma Ib G1-2 and Ia G3 in terms of OS, CSS and DFS. There weren’t statistically significant differences between tumors with or without lymph-vascular space invasion in terms of OS, CSS, DFS.Conclusion Statistically significant differences in survival in ST and CT were not obtained for intermediate risk. Despite this, CT appears to be a more appropriate method of treatment, which allows strengthening local control.