@article {Pietragalla1803, author = {Antonella Pietragalla and Martina Arcieri and Claudia Marchetti and Giovanni Scambia and Anna Fagotti}, title = {Ovarian cancer predisposition beyond BRCA1 and BRCA2 genes}, volume = {30}, number = {11}, pages = {1803--1810}, year = {2020}, doi = {10.1136/ijgc-2020-001556}, publisher = {BMJ Specialist Journals}, abstract = {Several genes associated with hereditary ovarian cancer have been discovered as a result of the work done with next generation sequencing. It is estimated that approximately 23\% of ovarian carcinomas have a hereditary predisposition. The most common hereditary condition is represented by germline mutations in BRCA1 or BRCA2 genes that account for 20{\textendash}25\% of high grade serous ovarian cancer. A number of other hereditary ovarian cancers are associated with different genes, with a crucial role in the DNA damage response pathway, such as the mismatch repair genes in Lynch syndrome, TP53 in Li-Fraumeni syndrome, STK11 in Peutz-Jeghers syndrome, CHEK2, RAD51, BRIP1, and PALB2. The goal of this manuscript is to summarize the published data regarding the molecular pathways involved in the pathogenesis of non-BRCA related hereditary ovarian cancer and to provide a tool that might be useful in discussing risk assessment, genetic testing, prevention strategies, as well as clinical and therapeutic implications for patients with ovarian cancer.}, issn = {1048-891X}, URL = {https://ijgc.bmj.com/content/30/11/1803}, eprint = {https://ijgc.bmj.com/content/30/11/1803.full.pdf}, journal = {International Journal of Gynecologic Cancer} }