RT Journal Article SR Electronic T1 Hematologic changes after splenectomy for ovarian cancer debulking surgery, and association with infection and venous thromboembolism JF International Journal of Gynecologic Cancer JO Int J Gynecol Cancer FD BMJ Publishing Group Ltd SP ijgc-2020-001368 DO 10.1136/ijgc-2020-001368 A1 Filippova, Olga T A1 Kim, Sun Woo A1 Cowan, Renee A A1 Chi, Andrew J A1 Iasonos, Alexia A1 Zhou, Qin C A1 Broach, Vance A1 Zivanovic, Oliver A1 Long Roche, Kara A1 Sonoda, Yukio A1 Gardner, Ginger A1 Chi, Dennis S YR 2020 UL http://ijgc.bmj.com/content/early/2020/07/12/ijgc-2020-001368.abstract AB Introduction The spleen plays a role in the immune and coagulative responses, yet a splenectomy may be required during ovarian cancer surgery to achieve complete cytoreduction. The aim of the study was to correlate hematologic changes with the development of infection and venous thromboembolism in patients undergoing splenectomy.Methods This single-institution retrospective review includes all patients undergoing splenectomy during cytoreductive surgery for advanced ovarian cancer, March 2001 to December 2016. We compared postoperative hematologic changes (evaluated daily before discharge) in patients developing infection within 30 days' post-surgery (Infection group) with those who did not (No-Infection group). We also compared patients developing venous thromboembolism with those without.Results A total of 265 patients underwent splenectomy. Median age was 64 years (range 22–88): 146 (55%) patients had stage IIIC and 114 (43%) patients had stage IV. The majority, 201 (76%) patients underwent splenectomy during primary debulking. A total of 132 (50%) patients comprised the Infection group (most common: urinary tract infection, 54%). Median time from surgery to infection was 8 days (range, 0–29). After initial rise in white blood cell count in both groups, the Infection group had a second peak on postoperative day 10 (median 16.6K/mcL, IQR 12.5–21.2) not seen in the No-Infection group (median 12K/mcL, IQR 9.3–16.3). A total of 40 (15%) patients developed venous thromboembolism, median time of 6.5 days (range, 1–43). All patients demonstrated a continuous rise in platelets during postoperative days 0–15. Thrombocytosis was present in 38/40 (95%) patients with venous thromboembolism vs 183/225 (81%) patients without (P=0.036). Median days with thrombocytosis was higher in venous thromboembolism (8 days, range 1–15) vs non groups (6 days, range 1–16, P=0.049).Conclusion We identified initial leukocytosis after splenectomy in all patients. The Infection group had a second peak in white blood cell count on postoperative day 10, not present in the No-Infection group. Among patients with venous thromboembolism, thrombocytosis was more frequent and of longer duration.