RT Journal Article SR Electronic T1 Letrozole in the management of advanced ovarian cancer: an old drug as a new targeted therapy JF International Journal of Gynecologic Cancer JO Int J Gynecol Cancer FD BMJ Publishing Group Ltd SP 1058 OP 1064 DO 10.1136/ijgc-2019-001128 VO 30 IS 7 A1 Claudia Marchetti A1 Francesca De Felice A1 Raffaella Ergasti A1 Giovanni Scambia A1 Anna Fagotti YR 2020 UL http://ijgc.bmj.com/content/30/7/1058.abstract AB At present, there is no standard of care on the use of letrozole in ovarian cancer management. We performed a systematic review of the available literature addressing this issue. Data demonstrated a role for letrozole in ovarian cancer, in both the primary and recurrent setting. Letrozole, which has a favorable toxicity profile, seems to assure a prolonged recurrence-free interval, particularly when used as maintenance treatment, in low grade serous ovarian cancer; in recurrent cases it had also led to prolonged disease control. However, the optimal setting and biologically relevant patient population needs to be defined in larger trials.