RT Journal Article SR Electronic T1 Placental site trophoblastic tumor in a patient with brain and lung metastases JF International Journal of Gynecologic Cancer JO Int J Gynecol Cancer FD BMJ Publishing Group Ltd SP 558 OP 563 DO 10.1136/ijgc-00009577-200405000-00023 VO 14 IS 3 A1 E. S. GUVENDAG GUVEN A1 S. GUVEN A1 I. ESINLER A1 A. AYHAN A1 T. KUCUKALI A1 A. USUBUTUN YR 2004 UL http://ijgc.bmj.com/content/14/3/558.abstract AB Placental site trophoblastic tumor is a rare neoplasm that arises from intermediate trophoblasts and shows diversity of biological behaviors, resulting in the absence of consistency in treatment modalities. A case of placental site trophoblastic tumor that extended to the cervix, with primary manifestation of amenorrhea and yellow foul-smelling vaginal discharge, is presented. Total abdominal hysterectomy was performed initially, and serial measurements of human chorionic gonadotropin levels were obtained. She was admitted with metastases to brain and lung 1.5 years after surgery. Combination chemotherapy (etoposide–methotrexate–dactinomycin/cyclophosphamide–vincristine) and radiotherapy were administered. There was no significant response to chemoradiotherapy. Despite changing chemotherapy regimen, she is still alive with progressive disease.