@article {MarchettiA51, author = {C Marchetti and MC Mele and E Rinninella and M Cintoni and P Raoul and G Scaletta and A Gasbarrini and G Scambia and A Fagotti}, title = {EP1227 Nutritional interventions to improve clinical outcomes in ovarian cancer: a systematic review of randomized controlled trials}, volume = {29}, number = {Suppl 4}, pages = {A51--A51}, year = {2019}, doi = {10.1136/ijgc-2019-ESGO.61}, publisher = {BMJ Specialist Journals}, abstract = {Introduction/Background Among all gynaecological neoplasms, ovarian cancer has the highest rate of disease-related malnutrition, representing an important risk factor of postoperative mortality and morbidity. Hence, the importance of finding effective nutritional interventions is crucial to improveovarian cancer patient{\textquoteleft}s well-being and survival.Methodology This systematic review of randomized controlled trials (RCTs) aims at assessing the effects of nutritional interventions on clinical outcomes such as overall survival, progression-free survival, length of hospital stay (LOS), complications following surgery and/or chemotherapy in ovarian cancer patients.Methods Three electronic bibliographic databases {\textemdash} MEDLINE, Web of Science and Cochrane Central Register of Controlled Trials - were used to conduct a systematic literature search based on fixed inclusion and exclusion criteria, until December 2018.Results A total of 14 studies were identified. Several early postoperative feeding interventions studies (n=8) were retrieved mainly demonstrating a reduction in LOS and an ameliorated intestinal recovery after surgery. Moreover, innovative nutritional approaches such as chewing gum intervention (n=1), coffee consumption (n=1), ketogenic diet intervention (n=2) or fruit and vegetable juice concentrate supplementation diet (n=1) and short-term fasting (n=1) have been shown as valid and well-tolerated nutritional strategies improving postoperative care.Conclusion despite an acceptable number of prospective trials, there is still a lack of homogeneous and robust endpoints. In particular, there is an urgent need ofRCTs evaluating overall survival and progression-free survival during ovarian oncology treatments. Further high-quality studies are warranted, especially prospective study and large RCTs, with more homogeneous types of intervention and clinical outcomes, including a more specific sampling of ovarian cancer women, to identify appropriate and effective nutritional strategies for this cancer at high risk of malnutrition.Disclosure Nothing to disclose.}, issn = {1048-891X}, URL = {https://ijgc.bmj.com/content/29/Suppl_4/A51.1}, eprint = {https://ijgc.bmj.com/content/29/Suppl_4/A51.1.full.pdf}, journal = {International Journal of Gynecologic Cancer} }