PT  - JOURNAL ARTICLE
AU  - M. Moodley
AU  - J. Moodley
AU  - I. Kleinschmidt
TI  - Invasive cervical cancer and human immunodeficiency virus (HIV) infection: a South African perspective
AID  - 10.1136/ijgc-00009577-200105000-00005
DP  - 2001 May 01
TA  - International Journal of Gynecologic Cancer
PG  - 194--197
VI  - 11
IP  - 3
4099  - http://ijgc.bmj.com/content/11/3/194.short
4100  - http://ijgc.bmj.com/content/11/3/194.full
SO  - Int J Gynecol Cancer2001 May 01; 11
AB  - The aim of this study was to compare the prevalence and presentation of cervical cancer in HIV-positive and HIV-negative women in our local population. Six hundred and seventy-two patients with cervical cancer presented to the gynecology oncology unit of King Edward VIII Hospital, South Africa. The HIV seroprevalence among these patients was 21%. There was an increase in the background prevalence of HIV infection (1.6–32.5%) as well as a quadrupling in the prevalence of HIV infection among patients with invasive cervical cancer (5–21%) over a 10-year period. The mean ages of the HIV-negative patients and HIV-positive patients were 55.2 and 39.8 years, respectively. Most of the HIV-positive patients were in the 30- to 40-year-old age group (51%), whereas the majority of patients who were HIV negative were in the 50- to 60-year-old age group (36%). The majority of patients, irrespective of HIV status, were more likely to have late stage disease than early stage disease. There was an increase in HIV infection in patients with both types of background prevalence and among patients with invasive cervical cancer. The mean age of HIV-positive patients was 15 years younger than that of the HIV-negative patients. The majority of patients, irrespective of HIV status, presented with late stage disease.