PT  - JOURNAL ARTICLE
AU  - E.M. Hartenbach
AU  - A.K. Saltzman
AU  - C. B. Zachary
AU  - J.L. Osborne
AU  - T. Okagaki
AU  - L.B. Twiggs
TI  - Placental site trophoblastic tumor presenting with scalp metastases
AID  - 10.1136/ijgc-00009577-199607000-00016
DP  - 1996 Jul 01
TA  - International Journal of Gynecologic Cancer
PG  - 333--336
VI  - 6
IP  - 4
4099  - http://ijgc.bmj.com/content/6/4/333.short
4100  - http://ijgc.bmj.com/content/6/4/333.full
SO  - Int J Gynecol Cancer1996 Jul 01; 6
AB  - Placental site trophoblastic tumor (PSTT) usually presents with vaginal bleeding or amenorrhea and an enlarged uterus. Metastasis to the skin as the presenting sign, or as a metastatic site, has not been previously reported with PSTT. We report a case of PSTT in which the presenting sign was scalp metastases and the only other disease was a small focus in the uterus. The patient responded to multi-agent chemotherapy and repeated skin resection at the local site. She received 16 alternating cycles of etoposide-methotrexate-actinomycin D and cytoxan-oncovin (EMA/CO) and is currently without evidence of disease. Clinicians caring for reproductive age women should remain aware that gestational trophoblastic disease (GTD) may present in an unusual manner.