PT  - JOURNAL ARTICLE
AU  - Highley, M.S.
AU  - Samandas, N.
AU  - Ziras, N.
AU  - Morgan, M. M.
AU  - Hill, M.E.
AU  - Stein, R.
AU  - Barker, S.
AU  - Coleman, R.E.
AU  - Blake, P. R.
AU  - Morris, D.
AU  - Slevin, M. L.
AU  - Wiltshaw, E.
AU  - Harper, P.G.
TI  - A phase II study of ifosfamide and bleomycin in advanced or recurrent cervical carcinoma
AID  - 10.1136/ijgc-00009577-199607000-00014
DP  - 1996 Jul 01
TA  - International Journal of Gynecologic Cancer
PG  - 323--327
VI  - 6
IP  - 4
4099  - http://ijgc.bmj.com/content/6/4/323.short
4100  - http://ijgc.bmj.com/content/6/4/323.full
SO  - Int J Gynecol Cancer1996 Jul 01; 6
AB  - Thirty-seven patients with advanced or recurrent cervical squamous cell carcinoma were treated with ifosfamide 1.5 gm-2 on days 1-5 (with mesna as a uroprotector), and bleomycin 30 mg on day 1, every 3 weeks. A partial response rate of 21% (95% CI: 6-36%) was obtained in patients who had not received prior chemotherapy, with a median duration of response of 5 months. No complete responses were seen. The median survival of all patients was 6 months. Nausea and vomiting, white cell suppression and encephalopathy were the main toxic effects. The results suggest that the addition of bleomycin to ifosfamide is not advantageous and increases toxicity, and that the interaction between these two agents is not contributory to the activity of the bleomycin, ifosfamide and cisplatin combination regimen (BIP). The potentially more severe toxicity of combination regimens must be considered when treating this group of patients.