RT Journal Article
SR Electronic
T1 EP370 The efficacy of hysterectomy for local remnant or recurrent cervical cancer after radical radiotherapy
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP A251
OP A251
DO 10.1136/ijgc-2019-ESGO.429
VO 29
IS Suppl 4
A1 T Nakasone
A1 Y Shimoji
A1 Y Arakaki
A1 Y Taira
A1 T Nakamoto
A1 T Oyama
A1 W Kudaka
A1 Y Aoki
YR 2019
UL http://ijgc.bmj.com/content/29/Suppl_4/A251.2.abstract
AB Introduction/Background Radiation therapy is an effective treatment for cervical cancer (CC), but remains at a constant rate, and those cases have a poor prognosis. The purpose of this study was to examine the efficacy of adjuvant hysterectomy in local remnant or recurrent (LR) cases of CC after radical radiotherapy (RT).Methodology Between May 2007 and September 2018, 21 patients who underwent hysterectomy for LR CC after RT in our department were included in this study. We retrospectively reviewed their medical records for patient background, clinicopathological factors, complications and prognosis. LR CC was determined based on histopathological and imaging examinations 3 months after the end of treatment. We classified surgical specimens according to the treatment effect (effects 0–3) using histological effect criteria. In addition, we used the Kaplan-Meier and log-rank test for statistical analyses.Results The median patient age was 55 years, and the FIGO stages were IB2, IIB and IIIB in 11, 8 and 2 cases, respectively. Based on the histological type, there were 14 cases of squamous cell carcinoma and 7 of adenocarcinoma. Tumour markers (TM) were re-elevated in five cases. Perioperative complications included intraoperative bladder injury and postoperative pelvic abscess in two cases. The median observation period was 39 months, and there were 10 recurrences. The median progression-free survival (PFS) was 54 months, and the 3-year overall survival (OS) rate was 61.1%. With regard to prognostic factors, the treatment effect (effect 1 vs. effect 2/3) was significantly associated with PFS (p=0.008) and OS (p=0.023) and the re-elevation of TM was significantly associated with PFS (p=0.017).Conclusion Hysterectomy for LR CC after RT might be a tolerable treatment with a long-term prognosis. Histological treatment effect evaluation of surgical specimens might be useful in additional treatment assessment, and TM elevation might be useful in preoperative assessment.Disclosure Nothing to disclose.