RT Journal Article
SR Electronic
T1 EP814 TGFβ pathway activation is a predictor of progression free and overall survival in advanced high-grade serous ovarian cancer according to the surgical aggressiveness and rate of cytoreduction of different oncologic centers
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP A450
OP A450
DO 10.1136/ijgc-2019-ESGO.864
VO 29
IS Suppl 4
A1 Ceppi, L
A1 Grassi, T
A1 Romualdi, C
A1 Di Lorenzo, P
A1 Palazzi, S
A1 Biagioli, E
A1 Garbi, A
A1 Paracchini, L
A1 Landoni, F
A1 Aletti, GD
A1 Colombo, N
A1 Fruscio, R
A1 Marchini, S
A1 D’Incalci, M
YR 2019
UL http://ijgc.bmj.com/content/29/Suppl_4/A450.1.abstract
AB Introduction/Background The activation of TGFβ pathway in advanced stage high-grade serous ovarian cancer (HGSOC) has been found to be related to short progression free survival (PFS) and overall survival (OS). miRNA181a-5p was found to be a proxy of TGFβ activation. This prognostic role has been identified only in cohorts with low surgical complexity, we evaluated 2 cohorts with different surgical approaches.Methodology Series of HGSEOC from two centers (European Institute of Oncology, Milan, Cohort1; San Gerardo Hospital, Monza, Cohort2) were analyzed for clinical features and miRNA quantification to test their prognostic value using a Cox-proportional hazard regression model.Results 118 and 84 patients were included, respectively. Cohort1 versus Cohort2 was composed of similar FIGO stages, higher upper abdominal disease spread (UAD) (P<0.001), higher complexity score (CS) of 6.7±2.4 and 3.5±1.7 (P<0.001) and lower residual tumor (P<0.001). Cohort1 compared to Cohort2 was associated with a lower number of events of PFS and OS (P<0.0012).An optimized threshold of miR181a-5p expression to segregate patients according to their prognosis was identified (miR-low and miR-high): for Cohort1 no threshold was reached; for Cohort2 a threshold segregated PFS of 20.9 v. 9.6 months (P:0.0008) and OS of 60.3 v. 23.3 months (P:0.0008), respectively.In multivariate analysis, no significance was observed for miR-high in Cohort1. For Cohort2, miR-high was related to worse PFS (P:0.0002), and OS (P:0.007).Conclusion miR181a-5p was observed as a prognostic biomarker in HGSEOC in Cohort2, -less aggressive surgery-, instead no prognostic role was observed in Cohort 1 -aggressive surgery-. This question-generating analysis suggests that TGFβ activation, a proxy of tumor aggressiveness, might be withdrawn by an aggressive surgical approach.A prospective validation of miR181 role is needed, the translational ancillary study of the TRUST trial (NCT # 02828618) may answer this question.Disclosure Nothing to disclose.