PT  - JOURNAL ARTICLE
AU  - MC Ou
AU  - D Ou
AU  - CC Pang
TI  - EP1290 The possible role of cell polarity for cancer disease – the implication of cancer regression by human body axes interaction
AID  - 10.1136/ijgc-2019-ESGO.1295
DP  - 2019 Nov 01
TA  - International Journal of Gynecologic Cancer
PG  - A649--A650
VI  - 29
IP  - Suppl 4
4099  - http://ijgc.bmj.com/content/29/Suppl_4/A649.2.short
4100  - http://ijgc.bmj.com/content/29/Suppl_4/A649.2.full
SO  - Int J Gynecol Cancer2019 Nov 01; 29
AB  - Introduction/Background The human body anatomical axes (HBAAs) interaction shows an anti-inflammatory effect (Ou MC decrescendo phenomenon, OuDP, Am J Emerg Med. 2012) which indicates a normalization of dysfunctional cells and has shown to induce tumor regression (TJOG, 2017; Cancer arch, 2019).Methodology OuDPt is performed by putting the contralateral hand over the lesion along human body anatomical axis of left-right, dorsoventral or vertical axis by the patient.Results Ten patients with cancer diseases including gynecological cancers as uterine leiomyosarcoma (1/10), endometrial cancer (2/10), ovarian cancer (1/10) and breast cancer (1/10) showed initial cancer suppression or regression. However, long term follow up showed tumor regrowth in endometrial cancer (2/10) and the ovarian cancer.Conclusion The signaling system of embryonic axes has shown to impart polarization of individual cells in Drosophila. Normal cell polarity is essential for normal cell function. The effect of OuDP is rapid, which indicates a direct mending effect on cell function (ICST, 2015).Normalizing the tumor cells and microenvironment function may make tumor cells conform to the regulations with apoptosis, metastasis suppression, preventing uninhibited proliferation, minimizing angiogenesis and supervision by host immunological systems. Long term follow up of advanced cancer diseases treated with OuDP showed tumor regrowth after initial regression, which may be due to poor accessibility, insufficient efficacy or escape phenomenon. However, OuDP may be availed for an active prevention for cancer.Disclosure Nothing to discloseAbstract EP1290 Figure 1 The relation between OuDPt and stage II uterine endometrioid adenocarcinoma