RT Journal Article
SR Electronic
T1 137 The alteration of lipids and steroid hormones in breast tumors
JF International Journal of Gynecologic Cancer
JO Int J Gynecol Cancer
FD BMJ Publishing Group Ltd
SP A64
OP A64
DO 10.1136/ijgc-2019-IGCS.137
VO 29
IS Suppl 3
A1 N Kotrikadze
A1 I Nakashidze
A1 L Ramishvili
A1 M Alibegashvili
A1 N Petrovic
A1 T Peshkova
A1 B Sepiashvili
A1 M Gordeziani
A1 S Gupta
A1 M Vanidze
A1 A Kalandia
A1 S Ahmad
YR 2019
UL http://ijgc.bmj.com/content/29/Suppl_3/A64.1.abstract
AB Objectives Breast Cancer (BC) is the mostly spread malignant disease among women worldwide. Lipids play important roles in several biochemical pathways on molecular and cellular level, such as synthesis of steroid hormones, which contributes to the development of BC. Therefore, we investigated levels following plasma lipids: cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL) and triglycerides (TG), and sex-steroid hormones: progesterone (P), estradiol (E2) and testosterone (T) in pre-menopausal (20–45 years) women with benign or malignant breast tumors.Methods We studied the lipid profile among the pre-menopausal (20–45 years) women with breast tumors. Venous blood samples were tested for investigation investigation. P < 0.05 was regarded as statistically significant.Results According to our investigation, higher CHOL level were associated with benign (P=0.0002), and malignant (P=0.0001) tumors compared with control group. The level of HDL decreases in benign (P=0.0002) and malignant (P<0.001) tumor groups compared with the control group. LDL level was elevated in both groups, as well, in benign and malignant tumors respectively (P=0.002, P<0.001). VLDL level was also decreased in both tumor subtypes respectively (P=0.0003; P=0.0007) compare to control group. Similarly, TG level was increased in benign (P=0.0025), and in malignant breast tumors (P=0.002) compared with controls. E2 and T levels were elevated in tumors in tumor’s group (P<0.05).Conclusions Our investigation has shown the association between high levels of CHOL, LDL,TG, E2 and T with breast tumors. Lipid profile and steroid hormones may be used as relatively reliable prognostic marker for early breast cancer prevention and diagnostics.