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Notable surgical trials in gynecologic oncology: a 10-year overview
  1. José C Vilches1,
  2. María Clara Santía2,
  3. Elise Mann Yates2,
  4. Rene Pareja3,
  5. Manuel Lozano1 and
  6. Pedro T Ramirez2
    1. 1Department of Obstetrics and Gynecology, Hospital Quironsalud Malaga, Malaga, Spain
    2. 2Obstetrics and Gynecology, Houston Methodist Hospital, Houston, Texas, USA
    3. 3Gynecology, Gynecologic Oncology, Clinica ASTORGA, Medellin, and Instituto Nacional de Cancerología, Medellin, Colombia
    1. Correspondence to Dr José C Vilches, Department of Obstetrics and Gynecology, Hospital Quironsalud Malaga, Malaga, 29004, Spain; jcvilches{at}


    In the last decade, we have witnessed important advances in novel therapeutics in the management of gynecologic cancers. These studies have built on the findings from preexisting data and have provided incremental contributions leading to changes that have not only impacted the accuracy of cancer detection and its metastatic components but also led to improvements in oncologic outcomes and quality of life. Key landmark trials have changed the standard of care in cervix, uterine, and ovarian cancer. A number of these have been controversial and have generated significant debate among gynecologic oncologists. The main objective of this review was to provide an overview on each of these trials as a reference for immediate and consolidated access to the study aims, methodology, results, and conclusion.

    • Vulvar and Vaginal Cancer
    • Endometrial Neoplasms
    • Cervix Uteri
    • Ovarian Cancer

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    • X @claritasantia, @RParejaGineOnco, @pedroramirezMD

    • Contributors JCV: conceptualization, investigation, writing original draft, writing review and editing. MCS: investigation, writing original draft, writing review and editing. EMY: investigation, review and editing. RP: investigation, writing review and editing. ML: investigation, writing review and editing. PTR: conceptualization, investigation, writing review and editing, project administration, project supervision.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.