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Impact of gynecological cancers on health-related quality of life: historical context, measurement instruments, and current knowledge
  1. Blanca Gil-Ibanez1,2,
  2. Jennifer Davies-Oliveira3,4,
  3. Gregorio Lopez1,2,
  4. Berta Díaz-Feijoo5,
  5. Alvaro Tejerizo-Garcia1,2 and
  6. Jalid Sehouli6
  1. 1Gynecologic Oncology and Minimally Invasive Surgery Unit, Gynecology and Obstetrics Department, Hospital Universitario 12 de Octubre, Madrid, Spain
  2. 2i+12 Research Institute, Hospital Universitario 12 de Octubre, Madrid, Spain
  3. 3Division of Cancer Sciences, The University of Manchester, Manchester, UK
  4. 4Department of Obstetrics and Gynaecology, St Mary’s Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK
  5. 5Institute Clinic of Gynecology, Obstetrics and Neonatology, Hospital Clinic de Barcelona, Institutd'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain
  6. 6Department of Gynecology with Center of Oncological Surgery, European Competence Center of Ovarian Cancer, Charité, University of Berlin, Berlin, Germany
  1. Correspondence to Dr Blanca Gil-Ibanez, Gynecologic Oncology and Minimally Invasive Surgery Unit, Gynecology and Obstetrics Department, Hospital Universitario 12 de Octubre, Madrid, Spain; blancalabacin{at}


Gynecologic cancers, comprising 14.4% of newly diagnosed cancer cases in women globally, are substantial causes of both mortality and morbidity, with a profound impact on the quality of life (QoL) of survivors. Over the past few decades, advancements in interdisciplinary and interprofessional care have contributed to an increase in the average life expectancy of gynecological cancer patients. However, the disease and its treatments have a profound impact on patients, leading to physical changes and psychological consequences, including psychosocial and psychosexual effects, which negatively affect their QoL.

The primary objective of management strategies is to minimize harm while improving survival rates and enhancing QoL during the survivorship stage. QoL measures play a crucial role in enhancing our comprehension of how cancer and its treatments affect individuals. Consequently, various measurement instruments, such as the EORTC QLQ 30, PROMIS-29, FACT-G, and QOL-CS, have been developed to assess health-related quality of life (HRQoL). Pre- and post-treatment HRQoL measurements have been shown to be predictive factors for post-operative complications and prognostic factors for overall survival and progression-free survival in gynecological oncology patients. Patient-reported outcomes related to HRQoL are essential tools for measuring patient outcomes and enabling patient-centered clinical decision-making.

This article focuses on HRQoL, providing a historical context, summarizing measurement instruments, and discussing the current understanding of the impact of gynecological cancers on HRQoL.

  • Quality of Life (PRO)/Palliative Care
  • Gynecologic Surgical Procedures
  • Surgical Oncology

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  • BG-I and JD-O contributed equally.

  • Contributors BG-I, JD-O, and GL contributed to the conception and design of the study and drafted the manuscript. BD-F, AT-G, and JS provided critical review of the content. All authors have read and approved the final version of the manuscript for publication.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.