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Original research
Cisplatin plus paclitaxel and bevacizumab versus carboplatin plus paclitaxel and bevacizumab for the first-line treatment of metastatic or recurrent cervical cancer
  1. Yusuf Ilhan1,
  2. Ali Murat Tatli1,
  3. Fatih Teker2,
  4. Arif Hakan Onder3,
  5. Fatih Kose4,
  6. Caglayan Geredeli5,
  7. Mustafa Karaagac6,
  8. Muhammet Ali Kaplan7,
  9. Mevlude Inanc8,
  10. Sabin Goktas Aydin9,
  11. Aysegul Kargi10,
  12. Hacı Arak2,
  13. Banu Ozturk3,
  14. Ali Ayberk Besen4,
  15. Oguzhan Selvi5,
  16. Mustafa Korkmaz6,
  17. Zeynep Oruc7,
  18. Oktay Bozkurt8,
  19. Ahmet Bilici9,
  20. Selami Bayram3,
  21. Shute Ailia Dae4,
  22. Mustafa Ozdogan10,
  23. Hasan Senol Coskun1 and
  24. Sema Sezgin Goksu1
  1. 1Department of Medical Oncology, Akdeniz University, Antalya, Turkey
  2. 2Department of Medical Oncology, Gaziantep University, Gaziantep, Turkey
  3. 3Department of Medical Oncology, Antalya Training and Research Hospital, Antalya, Turkey
  4. 4Department of Medical Oncology, Başkent Üniversitesi Adana Uygulama ve Araştırma Merkezi, Adana, Turkey
  5. 5Department of Medical Oncology, Okmeydani Training and Research Hospital, Istanbul, Turkey
  6. 6Department of Clinical Oncology, Necmettin Erbakan University Meram Faculty of Medicine, Konya, Turkey
  7. 7Department of Medical Oncology, Dicle University, Diyarbakir, Turkey
  8. 8Department of Medical Oncology, Erciyes University, Kayseri, Turkey
  9. 9Department of Medical Oncology, Istanbul Medipol University, Istanbul, Turkey
  10. 10Department of Medical Oncology, Medstar Antalya Hospital, Antalya, Turkey
  1. Correspondence to Dr Yusuf Ilhan, Department of Medical Oncology, Akdeniz University, Antalya, Turkey; dryusufilhan{at}gmail.com

Abstract

Objective Cisplatin-paclitaxel and bevacizumab is a frequently used treatment regimen for metastatic or recurrent cervical cancer, and carboplatin-paclitaxel and bevacizumab are also among the recommended regimens. In this study we aimed to evaluate the efficacy of these two regimens for the treatment of metastatic or recurrent cervical cancer.

Methods Patients with metastatic or recurrent cervical cancer treated with cisplatin-paclitaxel and bevacizumab or carboplatin-paclitaxel and bevacizumab were retrospectively evaluated in this study. The clinical and demographic characteristics of patients in each group were evaluated. Median overall survival, progression-free survival, and response rates between the two groups were compared.

Results A total of 250 patients were included. Overall, the numbers of patients with recurrent disease and metastatic disease were 159 and 91, respectively. The most common histologic subtype was squamous cell carcinoma (83.2%). The median duration of follow-up was 13.6 (range 0.5–86) months. The median progression-free survival was 10.5 (95% CI 9.0 to 11.8) months in the cisplatin-paclitaxel and bevacizumab group (group 1), and 10.8 (95% CI 8.6 to 13.0) months in the carboplatin-paclitaxel and bevacizumab group (group 2) (HR 1.20; 95% CI 0.88 to 1.63; p=0.25). The median overall survival was 19.1 (95% CI 13.0 to 25.1) months in group 1 and 18.3 (95% CI 15.3 to 21.3) months in group 2 (HR 1.28; 95% CI 0.91 to 1.80; p=0.15).

Conclusions There is no survival difference between cisplatin or carboplatin combined with paclitaxel and bevacizumab in metastatic or recurrent cervical cancer.

  • cervical cancer

Data availability statement

Data are available upon reasonable request. The datasets generated during and/or analyzed during this study are available from the corresponding author on reasonable request.

https://doi.org/10.1136/ijgc-2021-003165

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    Data availability statement

    Data are available upon reasonable request. The datasets generated during and/or analyzed during this study are available from the corresponding author on reasonable request.

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    Footnotes

    • Contributors The project was managed by YI. Clinical data were collected by YI, FT, AHO, FK, CG, MK, MAK, MI, SGA, AK, HA, BO, AAB, OS, MK, ZO, OB, AB, SB, SAD, and MO. The final manuscript was approved by all authors. The study concept was developed by AMT, HSC, and SSG. Manuscript drafting was done by YI and was reviewed and edited by AMT. YI is the guarantor and accepts full responsibility for the work and/or the conduct of the study, had access to the data, and controlled the decision to publish.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.