Rucaparib maintenance treatment for recurrent ovarian carcinoma: the effects of progression-free interval and prior therapies on efficacy and safety in the randomized phase III trial ARIEL3

Andrew R Clamp; Domenica Lorusso; Amit M Oza; Carol Aghajanian; Ana Oaknin; Andrew Dean; Nicoletta Colombo; Johanne I Weberpals; Giovanni Scambia; Alexandra Leary; Robert W Holloway; Margarita Amenedo Gancedo; Peter C Fong; Jeffrey C Goh; David M O’Malley; Deborah K Armstrong; Susana Banerjee; Jesus García-Donas; Elizabeth M Swisher; Terri Cameron; Sandra Goble; Robert L Coleman; Jonathan A Ledermann

doi:10.1136/ijgc-2020-002240

Article info

other Versions

You are currently viewing an earlier version of this article (January 09, 2022).
View the most recent version of this article

Original research

Rucaparib maintenance treatment for recurrent ovarian carcinoma: the effects of progression-free interval and prior therapies on efficacy and safety in the randomized phase III trial ARIEL3

Authors

Andrew R Clamp Department of Medical Oncology, The Christie NHS Foundation Trust and University of Manchester, Manchester, UK PubMed articles Google scholar articles
Domenica Lorusso Multicentre Italian Trials in Ovarian Cancer and Gynecologic Malignancies and Gynecologic Oncology Unit, Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy PubMed articles Google scholar articles
Amit M Oza Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada PubMed articles Google scholar articles
Carol Aghajanian Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA PubMed articles Google scholar articles
Ana Oaknin Gynaecologic Cancer Programme, Vall d'Hebron Institute of Oncology (VHIO), Hospital Universitari Vall d’Hebron, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain PubMed articles Google scholar articles
Andrew Dean Department of Oncology, St John of God Subiaco Hospital, Subiaco, Western Australia, Australia PubMed articles Google scholar articles
Nicoletta Colombo Gynecologic Cancer Program, University of Milan-Bicocca and European Institute of Oncology (IEO) IRCCS, Milan, Italy PubMed articles Google scholar articles
Johanne I Weberpals Ottawa Hospital Research Institute, Ottawa, Ontario, Canada PubMed articles Google scholar articles
Giovanni Scambia Gynecologic Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS and Scientific Directorate, Rome, Italy PubMed articles Google scholar articles
Alexandra Leary Gynecological Unit, Gustave Roussy Cancer Center, INSERM U981, and Groupe d’Investigateurs Nationaux pour l’Etude des Cancers Ovariens (GINECO), Villejuif, France PubMed articles Google scholar articles
Robert W Holloway Department of Gynecologic Oncology, Florida Hospital Cancer Institute, Orlando, Florida, USA PubMed articles Google scholar articles
Margarita Amenedo Gancedo Medical Oncology Department, Oncology Center of Galicia, La Coruña, Spain PubMed articles Google scholar articles
Peter C Fong Medical Oncology Department, Auckland City Hospital and University of Auckland, Auckland, New Zealand PubMed articles Google scholar articles
Jeffrey C Goh Department of Oncology, Cancer Care Services, Royal Brisbane and Women’s Hospital, Herston, Queensland, AustraliaUniversity of Queensland, St Lucia, Queensland, Australia PubMed articles Google scholar articles
David M O’Malley Division of Gynecologic Oncology, The Ohio State University, James Cancer Center, Columbus, Ohio, USA PubMed articles Google scholar articles
Deborah K Armstrong Oncology, Gynecology and Obstetrics, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, USA PubMed articles Google scholar articles
Susana Banerjee Gynecology Unit, The Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, UK PubMed articles Google scholar articles
Jesus García-Donas Division of Medical Oncology, HM Hospitales—Centro Integral Oncológico Hospital de Madrid Clara Campal, Madrid, Spain PubMed articles Google scholar articles
Elizabeth M Swisher Division of Gynecologic Oncology, University of Washington, Seattle, Washington, USA PubMed articles Google scholar articles
Terri Cameron Clinical Science, Clovis Oncology UK Ltd, Cambridge, UK PubMed articles Google scholar articles
Sandra Goble Biostatistics, Clovis Oncology, Inc, Boulder, Colorado, USA PubMed articles Google scholar articles
Robert L Coleman Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA PubMed articles Google scholar articles
Jonathan A Ledermann Department of Oncology, UCL Cancer Institute, University College London and UCL Hospitals, London, UK PubMed articles Google scholar articles

Correspondence to Dr Domenica Lorusso, Gynecologic Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Agostino Gemelli 8, 00168 Rome, Italy; domenica.lorusso{at}policlinicogemelli.it

View Full Text

Citation

Clamp AR, Lorusso D, Oza AM, et al

Rucaparib maintenance treatment for recurrent ovarian carcinoma: the effects of progression-free interval and prior therapies on efficacy and safety in the randomized phase III trial ARIEL3

International Journal of Gynecologic Cancer Published Online First: 08 June 2021. doi: 10.1136/ijgc-2020-002240

Publication history

Received November 9, 2020
Revision received April 20, 2021
Accepted April 26, 2021
First published June 8, 2021.

Article Versions

You are currently viewing a Previous version of this article (9 January 2022).
View the most recent version of this article

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Main menu

other Versions

Authors

Citation

Publication history

Article Versions

Request permissions

Copyright information

Log in using your username and password

Main menu

Log in using your username and password

You are here

other Versions

Authors

Citation

Publication history

Article Versions

Request permissions

Copyright information

Read the full text or download the PDF:

Log in using your username and password