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Adenosine triphosphate-based chemotherapy response assay predicts long-term survival of primary epithelial ovarian cancer
  1. Lan Ying Li,
  2. Sang Wun Kim,
  3. Eun Ji Nam,
  4. JungYun Lee,
  5. Sunghoon Kim and
  6. Young Tae Kim
  1. Department of Obstetrics and Gynecology, Women's Cancer Center, Yonsei cancer Center, Institute of Women’s Life Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea
  1. Correspondence to Sang Wun Kim, Department of Obstetrics and Gynecology, Institute of Women’s Life Medical Science, Yonsei University College of Medicine, Seoul 03722, Republic of Korea; san1{at}yuhs.ac

Abstract

Objective The aim of this study is to analyze the long-term relapse-free survival and overall survival outcomes of primary ovarian cancer patients using adenosine triphosphate-based chemotherapy response analysis.

Methods In total, 162 primary epithelial ovarian cancer patients who underwent chemotherapy response assay for carboplatin, cisplatin, and paclitaxel by adenosine triphosphate-based chemotherapy response analysis prior to chemotherapy between December 2006 and November 2016 were retrospectively reviewed. Chemosensitivity with single or combined three agents and clinical characteristics of patients were studied to understand their correlation with long-term relapse-free survival and overall survival.

Results Median follow-up time was 61.4 (range 1 – 130) months. Univariate analysis showed the paclitaxel-sensitive group (HR = 0.625, 95%CI = 0.393 to 0.994), combined carboplatin and paclitaxel-sensitive group (HR = 0.574, 95%CI = 0.352 to 0.937), and combined carboplatin, cisplatin, and paclitaxel-sensitive group (HR = 0.489, 95%CI = 0.295 to 0.810) were highly associated with better relapse-free survival than their corresponding non-sensitive groups. The carboplatin-sensitive group (HR = 0.533, 95%CI = 0.303 to 0.939), cisplatin-sensitive group (HR = 0.433. 95%CI = 0.251 to 0.748), and combined carboplatin- and cisplatin-sensitive group (HR = 0.286, 95%CI = 0.142 to 0.576) were highly associated with better overall survival than their corresponding non-sensitive groups. Combined carboplatin, cisplatin, and paclitaxel chemosensitivity, together with International Federation of Gynecology and Obstetrics (FIGO) stage were independent predictors for relapse-free survival. Single or combined chemosensitivity of cisplatin and/or carboplatin, together with residual tumor size and FIGO stage, were significant independent predictors for overall survival on a multivariate hazard model.

Conclusion Paclitaxel sensitivity is a prognostic factor of long-term relapse-free survival in patients with epithelial ovarian cancer, but platinum sensitivity is a more important prognostic factor for long-term overall survival.

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Footnotes

  • Funding This study was supported by a faculty research grant of Yonsei University College of Medicine (6-2009-0192 and 6-2014-0003) and the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology (NRF-2011-0013127 and NRF-2014R1A1A2053635).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned, externally peer reviewed.

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