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Serous and mucinous borderline tumors of the ovary: a clinicopathologic and DNA-ploidy study of 102 cases
  1. T. Kuoppala*,
  2. M. Heinola*,
  3. R. Aine,
  4. J. Isola and
  5. P.K. Heinonen*,
  1. Departments of *Obstetrics and Gynecology, and †Pathology, University Hospital of Tampere, and ‡Medical School, University of Tampere, FIN-33101 Tampere, Finland
  1. Address for correspondence: Dr P. K. Heinonen, Medical School, University of Tampere, Box 607, FIN-33101 Tampere, Finland.


One-hundred and two patients with epithelial borderline ovarian tumors treated at Tampere University Hospital between January 1965 and September 1991 were evaluated. There were 48 patients with serous tumors and 54 with mucinous tumors. Ninety-three (91%) patients had clinical stage I and nine had stage III disease. Abdominal hysterectomy and bilateral salpingo-oophorectomy were performed in 70% of the patients. Forty percent of those with serous and 20% with mucinous tumors were operated conservatively. After conservative surgery six patients had a total of 10 deliveries and none of these had a recurrence. Seven patients received chemotherapy, none had radiation therapy. An aneuploid DNA pattern was identified in 8.2% of 85 specimens studied and a high S-phase fraction was found in 8.6% of 81 specimens studied. DNA measurement failed to identify the malignantly behaving tumors. Elevated preoperative serum levels of CA125 were found in 10(63%) out of 16 cases studied. All of them dropped postoperatively to normal. During the follow-up period (mean 11.6 years, range 4.5-29.7 years) 22 patients died but in 17 of them death was unrelated to ovarian tumor. The corrected (borderline malignancies related) 5-year survival rate was 100% in patients with serous tumor and 96% with mucinous tumor, 25-year survival rate was 97% and 91%, respectively. There was no difference between the serous and mucinous groups. Our results show that ovarian borderline tumors have a good prognosis. Quite conservative therapy is often enough, especially in low-stage disease in young women who want to retain their fertility.

  • borderline
  • CA125
  • flow cytometry
  • mucinous
  • ovarian tumors
  • serous

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