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Raised serum squamous cell carcinoma antigen levels in malignant transformation of mature cystic ovarian teratoma
  1. H. W.A. De Bruijn*,
  2. P. H. B. Willemse,
  3. K.A. Ten Hoor* and
  4. H. Boonstra*
  1. Departments of *Obstetrics and Gynaecology, †Pathology and‡Internal Medicine, University Hospital, Groningen, the Netherlands
  1. Address for correspondence: Dr H. W. A. de Bruijn, Laboratory Obstetrics and Gynaecology, University Hospital, Oostersingel 59, NL-9713 EZ Groninger, the Netherlands.


Mature cystic ovarian teratoma with malignant transformation to squamous cell carcinoma was diagnosed in four patients. Squamous cell carcinoma (SCC) antigen serum levels were elevated at diagnosis and during progression of the disease, but normal in complete remission. Elevated serum SCC antigen levels were also found in four out of 19 patients with mature cystic teratoma of the ovary. Cystic fluid from mature cystic teratoma could contain very high levels of the SCC antigen (> 1000 µg 1-1) without any sign of malignant transformation.

  • malignant transformation
  • mature cystic teratoma of the ovary
  • squamous cell carcinoma antigen

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