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Expression of integrin adhesion molecules in normal ovary and epithelial ovarian tumors
  1. J. E. Bridges*,
  2. P. Englefield,
  3. I. E. Boyd*,
  4. W. R. Roche and
  5. E. J. Thomas
  1. * Department of Obstetrics and Gynaecology, Princess Anne Hospital, Southampton,
  2. University Pathology, Southampton General Hospital and
  3. University Obstetrics and Gynaecology, Princess Anne Hospital, Southampton, UK
  1. Address for correspondence: Miss J. Bridges, Chelsea & Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK.


The metastatic potential of a solid tumor is dependent upon its ability to interact with the extracellular matrix. The integrin superfamily is a group of proteins that are fundamental in such interactions and play a major role in cell-cell and cell-matrix adhesion. Localization of the integrin proteins was performed in normal ovary, primary epithelial ovarian tumors and metastatic tumor cells in ascitic samples. Expression of α1, α3, α6 and β4 was observed on normal ovarian epithelium with variable expression of α5. Loss of α1 expression by malignant cells in the primary tumors was noted. β4, a component of the laminin receptor which was strongly expressed by both normal ovary and solid tumor, was absent from the ascitic tumor cells in the majority of cases. There was an associated loss of α6 expression, indicating a deficiency of hemidesmosomes in the ascitic tumor cells. This alteration of integrin expression by metastatic malignant epithelial ovarian tumor cells may therefore represent one important mechanism by which metastatic disease occurs.

  • epithelial ovarian cancer
  • integrins.

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