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DNA-ploidy and mutant p53 overexpression in primary fallopian tube cancer
  1. A.-C. HELLSTRÖM*,
  2. J. HUE*,
  3. C. SILFVERSWÄRD† and
  4. G. AUER†
  1. *Department of Gynaecology and Oncology, Radiumhemmet
  2. †Department of Tumor Pathology, Karolinska Hospital and Institute, Stockholm, Sweden
  1. Address for correspondence: Ann-Cathrin Hellström, Department of Gynaecology and Oncology, Radiumhemmet, Karolinska Hospital, S-171 76 Stockholm, Sweden.

Abstract

Nuclear DNA content and p53 immunoreactivity were determined in 53 cases of primary fallopian tube cancer (PFTC). All tumors showed a distinctly aneuploid DNA distribution pattern, whereas p53 immunoreactivity was observed in 51% of the cases. If the patients were divided into two groups according to survival time, p53 immunoreactivity was present in 40% of the tumors from patients surviving for more than 8 years and in 65% of tumors from patients who died within 2 years. This difference was not statistically significant (P = 0.438). Patient survival was significantly correlated to the clinical stage (FIGO) (P = 0.0009).

  • p53
  • ploidy
  • primary fallopian tube cancer
  • staging

https://doi.org/10.1046/j.1525-1438.1994.04060408.x

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    Footnotes

    • This study was supported by the Cancer Society in Stockholm.