Article Text

Download PDFPDF
EV479/#1103  Risk of subsequent vaginal cancer after cervical and vulvar cancer: a seer-based study
  1. Heyang Xu1,
  2. Wanna Chen2,
  3. Yanna Liu1,
  4. Shaoqiong Deng1 and
  5. Li Sun1
  1. 1National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China
  2. 2The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

Abstract

Introduction The risk of vaginal cancer subsequent to cervical and vulvar cancer is still unclear. The aim of the study is to estimate the risk of subsequent vaginal cancer after cervical and vulvar cancer in real-world population, analyze the risk factors and explore the effect of HPV on this process.

Methods Cases diagnosed with cervical, vulvar and vaginal cancer were identified from SEER 18 1975-2016 database. Cumulative incidences of subsequent vaginal cancer occured at least 6 months after cervical and vulvar cancer were estimated using competing risk model. Risk factors of subsequent vaginal cancer and effect of HPV on this process were analysis.

Results 93272 patients with cervical cancer and 58661 patients with vulvar cancer were included in analysis. The 40-year cumulative incidence of subsequent vaginal cancer was 1.15% after cervical cancer and 1.40% after vulvar cancer. Elder age was a common risk factor of subsequent vaginal cancer. HPV-related vulvar cancer, compared with others, showed a higher cumulative incidence of subsequent HPV-related vaginal cancer. The 40-year cumulative incidences of subsequent HPV-related vaginal cancer were 0.98% after HPV-related cervical cancer and 1.32% after HPV-related vulvar cancer. The overlaps of cervical, vulvar and vaginal cancer were larger within histological types related to HPV than those not related to HPV.

Conclusion/Implications This population-based study showed that the cumulative incidences of subsequent vaginal cancer after cervical and vulvar cancer were beyond one percent, HPV and elder age had essential effect on this process, which suggest a closer follow-up for this high-risk population.

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.