Introduction Squamous cell carcinoma of vulva is uncommon. Radical wide local excision and vulvectomy were common surgical approach. Various studies had shown different significance of margin status in terms of recurrence. This is a study to identify the relationship in a local tertiary centre in Hong Kong.

Methods This is a retrospective study. Patients who had undergone radical wide local excision or vulvectomy for indication of squamous cell carcinoma of vulva in Queen Elizabeth Hospital of Hong Kong within the period between 1^stJanuary 2014 and 31^st December 2023 were included. Follow-up was arranged until patient deceased. Patients who defaulted follow-up and could not be contacted were excluded. Data was processed by IBM SPSS. Different cut-offs for close margin were used from 1mm to 10mm (at 1mm interval). Multiple logistic regression was used to adjust confounding factors including tumour size, any known groin lymph node metastasis, lymphovascular space invasion, depth of invasion, differentiation, smoking, and any adjuvant radiotherapy.

Results Total 20 patients were analyzed. 60% of them (n=14) was diagnosed to be FIGO 2009 stage 1B disease. Median pathological margin was 3.5mm (range 0mm to 12mm). 3 patients developed recurrence. Median age at time of surgery was 77.3 years old. Median duration of follow-up interval was 35.5 months. No statistically significant difference was demonstrated in recurrence rate using different cut-offs of pathological margin.

Conclusion/Implications This is the first article to review the local data in Hong Kong. Statistically significant difference was not demonstrated in terms of recurrence rate using different cut-off of pathological margin.