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PT008/#908  The menopause after cancer (MAC) study – multimodal, technology-assisted intervention for the management of menopause after cancer improves insomnia symptoms
  1. Fionan Donohoe1,
  2. Teresa Treacy1,
  3. Aidin Roberts1,
  4. Helen Ryan1,2,
  5. Yvonne O’meara1 and
  6. Donal Brennan3
  1. 1Living Well Cancer Programme, Gynaecological Oncology, Dublin, Ireland
  2. 2Mater Misericordiae University Hospital, Gynaecological Oncology Department, Dublin, Ireland
  3. 3UCD Gynaecological Oncology Group, Ucd School of Medicine, Mater Misericordiae University Hospital, Dublin, Ireland

Abstract

Introduction Sleep disturbance is commonly experienced by cancer survivors, with rates ranging from 25-59%. Often this can be due to vasomotor symptoms (VMS), particularly in women who are ineligible for menopause hormonal therapy.

Methods The MAC Study ((NCT04766229) was a prospective, single arm, phase 2 trial examining the impact of a composite intervention consisting of -Non-hormonal pharmacotherapy to manage VMS -Digital CBT for insomnia (dCBT-I) through Sleepio (BigHealth) -Self-management strategies for VMS, -Nominated support person. The trial met its primary endpoint, improvement cancer-specific global quality of life (QOL), here we present data on sleep outcomes as a secondary end point.

Results 204 women (82% history of breast cancer). were recruited, with a median age of 49, (range 28 – 66). 93% met diagnosis criteria for insomnia (SCI<16) at baseline, which reduced to 45.2% at 6 months (p<0.001). The mean SCI score increased from 8.5 (SEM 0.4) to 17.3 (SEM0.5) at 6 months (p<0.0005). Clinically relevant changes were seen in sleep parameters, with sleep onset latency reducing by 13.6 minutes after completion of dCBT-I (p<0.001). A 35 minute reduction in wakefulness after sleep onset was also seen (p<0.001) alongside a 29.1% improvement in sleep quality (p<0.001). Comparison of breast cancer and non-breast cancer patients demonstrated the intervention was equally effective in both groups.

Conclusion/Implications The MAC study demonstrated that a targeted composite intervention can improve sleep and self-reported insomnia symptoms for women with troublesome VMS after a cancer diagnosis, which contributed to an improvement in cancer specific global QOL.

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