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EV349/#210  Prognostic significance of neutrophil–lymphocyte and platelet–lymphocyte ratios in patients with epithelial ovarian cancer
  1. Aref Zribi,
  2. Amnah Faisal Ahmed,
  3. Hasan Khalid Alsayegh and
  4. Ikram A Burney
  1. SQCCCRC, Muscat, Oman

Abstract

Introduction Ovarian cancer ( OC) is one of the most common cancers with poor prognosis worldwide. Neutrophil-lymphocyte ratio (NLR) and Platelet–Lymphocyte Ratio (PLR) are biomarkers that reflect severe inflammation. The prognostic role of NLR and PLR in patients with OC remains inconsistent. This study was conducted to evaluate the predictive value of NLR/PLR for prognosis in OC patients.

Methods We retrospectively reviewed 32 patients with epithelial OC treated in SQCCCRC between January 2022 and December 2023. The clinicopathologic records and complete blood counts of the patients were analysed.

Results Thirty-two epithelial OC patients were included in the analysis. Most of the patients (45%) were diagnosed at stage III, 53% were high grade serous ovarian cancer ( HGSOC), 25% of patients were BRCA mutant and 45,5% were HRd. Decrease in NLR from the baseline were statistically significant at 3- and 6-months of follow up post-treatment in patients without any recurrence of the disease ( p-values= 0.04 and 0.0049 respectively), Changes in NLR and PLR were not significantly different between the BRCA wt and mutant groups or between the HRd and HRp groups. Baseline NLR was higher in the HGSOC group comparing to the other histology. Higher baseline NLR/PLR levels were found in the high CA125 group (CA125 ≥35).

Conclusion/Implications Assessing NLR and PLR levels is simple and inexpensive based on the available complete blood counts. NLR levels were higher in patient with HGSOC and patients with CA125 ≥35. NLR/PLR levels can be used as predictor of poor prognosis of OC.

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