Introduction Factors influencing the survival of women with ovarian cancer have been reported. However, only a few studies reported comparisons between the laparotomic and laparoscopic surgical approach. The NCCN guideline has mentioned that the laparoscopic approach may be considered in selected patients with early-stage ovarian cancer. However, Cochrane reviews have not found good quality evidence to help quantify the risks and benefits of laparoscopy for the treatment of early-stage ovarian cancer as a routine clinical practice. Therefore, the objective of our study was to investigate the clinical outcome of laparoscopic surgery for the treatment of early-stage ovarian cancer, compared to the laparotomic approach.

Methods The medical records of all consecutive women with early-stage ovarian cancer who received laparotomic or laparoscopic surgical treatment at a tertiary referral center were reviewed. Women with ovarian borderline tumors were excluded.

Results A total of 132 women were reviewed (table 1). Multivariable analysis revealed that an increased body mass index and the presence of residual tumor were associated with a decrease in progression-free survival. However, a higher baseline CA125 value, laparotomy use (adjusted hazard ratio = 0.103, p = 0.017, figure 1) and increased chemotherapy cycles were associated with better progression-free survival (table 2). Multivariable analysis revealed that a higher baseline CA125 value and increased chemotherapy cycles were associated with better overall survival (table 3).

Conclusion/Implications Women with early-stage ovarian cancer who received laparoscopic surgical treatment appear to be associated with a shorter progression-free survival, compared with laparotomy.

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Abstract EV269/#276 Figure 1

Comparison of progression-free survival of women with early-stage ovarian cancer between the laparotomic and laparoscopic surgical