Introduction Cancer can have an impact on Quality of Life (QoL), which can be influenced by an individual’s culture and value system.

Methods We conducted a cross-sectional descriptive survey involving all women with gynecological malignancies who were receiving care at Ahmadu Bello University Teaching Hospital in Zaria between May 2022 and April 2024. The WHOQOL BREF was used to assess QoL. Scores greater than one standard deviation above the mean were considered good, scores less than one standard deviation below the mean were regarded as poor, while scores that fell between them were deemed fair.

Results The mean age of respondents was 49.4 ± SD15.0 years. The mean scores for overall QoL and overall health were 3.18 ± SD 1.1 and 3.10 ± SD 1.1, respectively. A total of 26% of the participants had a poor overall QoL and only 9.6% had a good overall QoL. The QoL was significantly affected by the stage of the disease (p=0.04) and treatment status (p=0.02). The overall health was good only in 9.6% of the participants and was found to be significantly affected by the stage of the disease (p=0.01). Sociodemography and cancer type were not associated with QoL and overall health scores. The majority of the participants reported fair QoL across the physical health (83.6%), psychological health (79.5%), social relationships (71.2%), and environmental domains (72.6%). The psychological health domain had the highest number of participants with poor QoL (16.4%).

Conclusion/Implications QoL concerns need to be addressed while offering care for women with gynaecological malignancies.