Introduction The purpose of this study is to describe the clinico-pathological characteristics and treatment outcomes of patients with uterine sarcoma treated at Moi Teaching and Referral Hospital (MTRH). There is also not much known about uterine sarcoma in Kenya and the East African sub-region.

Methods This is a retrospective study conducted over a ten-year period (2013 to 2023) at MTRH. Relevant clinical characteristics of patients were collected including survival information from prospectively kept patients‘ data base. Approval to conduct the study was obtained from the institution’s Review and Ethic Committee.

Results A total of 56 histological confirmed cases of uterine sarcoma were identified and managed at MTRH. Ninety-seven percent of patients underwent total abdominal hysterectomy plus/minus bilateral salpingo-oophorectomy. Fifty percent received adjuvant chemotherapy while less than 10% received radiotherapy. Table I. About twenty-five percent of patients developed recurrence following treatment. Recurrences in the abdomen and lungs were 46.1% and 30.8% respectively. The mortality rate was 61% and patients that presented with stage III and IV disease had the worst survival outcomes despite standard treatment. The median overall survival time was 17 months while the median progression-free survival time was 14 months irrespective of adjuvant trement. The one-year and 3-years overall survival were 57% and 39%. Table II.

Conclusion/Implications Clinical stage was the most important prognostic factor and stage III and IV patients had poor survival outcomes despite standard treatment. This study may serve as a foundation for a more comprehensive multicenter study of uterine sarcoma in Kenya and the East African sub-region.