Introduction Salvage hysterectomy in patients after radiation in locally advanced cervical cancer: a single centre prospective longitudinal study.

Methods The aim of the study was to evaluate the efficacy of hysterectomy in the control of pelvic disease in patients with post-irradiated cervical cancer with residual/recurrent disease. Prospective observational study from locally advanced cervical carcinoma(IIB-III) patients in Gynec oncology & Radiation oncology department in AHPGIC .Study Period : 3 years , Sample Size: 30 patients

Results Some of the factors which had significant association with recurrences post salvage hysterectomy were non administration of Preoperative Brachytherapy, non squamous histology, deep stromal invasion, positive surgical margins . Post-operative complications were seen but the incidence was not high . 11early complications & 10 late complications (only 6 grade 3 Clavien dindo complications ) have been observed , which were not life threatening and were managed conservatively. 1 yr DFS rate was 83.33% in our study.

Conclusion/Implications The most important determinant of survival is to achieve negative surgical margins rather than radicality of surgery. This study shows that radical hysterectomy is feasible with good outcome and acceptable morbidity after chemoradiotherapy in cervical cancer patients ‘IF SELECTION OF PATIENTS IS APPROPRIATE.’