Introduction LACC trial showed that minimally invasive radical hysterectomy was associated with lower rates of disease-free and overall survival than open abdominal radical hysterectomy among women with early-stage cervical cancer. We would like to retrospectively review the oncologic outcome of laparoscopic radical hysterectomy in our university hospital. The primary objective of this study was to compare 2-year disease free survival rate between laparoscopic radical hysterectomy with pelvic lymphadenectomy (LRHPL) and transabdominal radical hysterectomy with pelvic lymphadenectomy (ARHPL) for patients with stage IA2-IIA1 cervical cancer.

Methods A retrospective study with age and clinical tumor size matching was done to balance between 2 groups. The ratio between cases (LRHPL) and control (ARHPL) was 1:2. 263 patients with stage IA2-IIA1 cervical cancer between January 2005 and June 2017 were included in the study. The operation was performed by experience gynaecologic oncology laparoscopists at Faculty of Medicine Siriraj Hospital. Patients characteristics, surgical and oncological outcomes were compared between two groups.

Results A total of 86 patients underwent LRHPL and 177 patients underwent ARHPL. The two groups were similar with baseline characteristics. The 2-year disease free survival rate was 91.8% in LRHPL group and 96% in ARHPL group (p=0.19). The 2-year overall survival was 97.6% in LRHPL group and 99.4% in ARHPL group (p=0.20). LRHPL group had less median blood loss and lower rate of blood transfusion. However, LRHPL group had longer mean operative time.

Conclusion/Implications In our study, 2-year disease free survival and 2- year overall survival rate appeared no statistically significant different between LRHPL and ARHPL group.