Introduction/Background More than 100 types of human papillomaviruses (HPVs) have been identified and approximately half of them infect the genital tract. Many types of HPV have been found in cervical cancers, which gives rise to the nomenclature of ‘high-’ and ‘low-risk’ HPVs. HPV peaks in young women around age of sexual debut and declines in the late 20s and 30s. But women’s risk for HPV is not over yet: There is sometimes a second peak around the age of menopause. The prevalence of HPV in menopause has increased in Europe and America. The cause of this increase is unclear but shows new attitudes towards sexuality or reactivation of previous infections.

Methodology 150 patients of the Women’s Center at ‘Queen Geraldine’ University Hospital were analyzed who had an abnormal PAP smear result during 2020.

38 of these patients underwent colposcopy and HPV DNA analysis.

Results 20 genotypes were identified.

24 (63%) patients had unique infection, 14 (37%) had multiple infection.

Genotypes 52–54, 16–18, 39–68,18–39,31–54,56–74,31–52 predominated.

The most associated genotypes were 31,52,54.

HPV 16 stood more alone.

Conclusion There is no cure for HPV, but 70% to 90% of infections are cleared by the immune system and become undetectable.HPV infection has increased in menopause. Diagnosis of HPV in menopause is made through pap test, colposcopy and HPV DNA analysis.

Disclosures The author declares that (s)he has no relevant or material financial interests that relate to the research described in this paper.