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398 Prognosis in locally advanced cervical cancer with pelvic lymph node metastases
  1. Ines Zemni1,2,
  2. Marwa Aloui1,
  3. Nadia Boujelbene2,3,
  4. Saida Sakhri1,
  5. Ines Zidi2 and
  6. Tarek Ben Dhiab1
  1. 1Department of Surgical Oncology, Salah Azaiez Institute, Faculty of Medicine of Tunis, Tunis, Tunisia
  2. 2Laboratory Microorganisms and Active Biomolecules, Sciences Faculty of Tunis, University Tunis El Manar, Tunis, Tunisia
  3. 3Department of Pathology, Salah Azaïz Institute, Faculty of Medicine, Tunis, Tunisia


Introduction/Background Lymph-node status is classically evaluated by lymph-node dissection. This surgical approach has mainly a prognostic interest. The purpose of this study was to investigate the prognosis of locally advanced cervical cancer with pelvic lymph node metastases.

Methodology We conducted a retrospective study at Salah Azaiez Institute of Oncology from January 1, 2010, to December 31, 2020, including 123 patients with locally advanced cervical cancer who underwent curative surgery with pelvic lymphadenectomy. All removed pelvic nodes were pathologically examined. Pelvic lymph node metastases were found in 14 cases.

Results Median age at diagnosis was 56.14 years (35–81). Among our 14 patients, 13 (92.9%) were diagnosed with squamous cell carcinoma and 1 (7.1%) with adenocarcinoma. The median tumor size at diagnosis was 48.21mm (10–80).

Two-year overall survival (OS) was 14.3%. High blood pressure (p=0.004) and OMS score (p=0.004) were risk factors for poor prognosis for these patients. OS survival was not significantly different for tumor size, cell type, lymphovascular space involvement (LVSI), and parametrial involvement.

Two-year disease-free survival (DFS) was 26.7%. Oral contraception (p=0.046), (LVSI) (p=0.046), and vaginal invasion (p=0.046) were prognostic factors that affected disease-free survival. DFS was not significantly different for tumor size (p=0.617), histological grade (p=0.194), and FIGO stage (p=0.608).

Conclusion Pelvic lymph-nodal involvement is a major prognostic factor in locally advanced cervical cancer.

Disclosures No conflict of interest.

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