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384 Effect of covid-19 pandemic on the care of patients with newly diagnosed cervical cancer
  1. Atefeh Rezaei1,
  2. Hadi Erfani2 and
  3. Karina Nieto1
  1. 1Seidman Cancer Institute, Cleveland, USA
  2. 2Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA


Introduction/Background The COVID-19 pandemic has resulted in major disruptions of the healthcare system, including cancer care. Our objective was to assess the impact of the COVID-19 pandemic on the time from diagnosis of cervical cancer to the time of initiation of radiation or surgical treatment.

Methodology The National Cancer Database (NCDB) was queried for the year 2020 for patients with histologically confirmed diagnosis of cervical cancer. The 2020 release of the NCDB data includes the COVID Testing and the status of the patients. Outcome variables were time from diagnosis to initiation of treatment (surgery, radiation therapy versus chemotherapy). Data were reported as median [interquartile range] and number [rate].

Results 4598 patients with newly diagnosed cervical cancer and documented COVID-19 testing were included; 364 (7.9%) tested positive and 4234 (92.1%) who remained negative for the duration of diagnosis and treatment. Characteristics including age, race, education and insurance status were similar (p = NS).

Median time from the diagnosis to the first surgical procedure was 14 [5, 43] in the COVID negative group versus 31 [10, 72] days in the COVID positive group (P=0.04). The time from diagnosis to the first radiation treatment was 35 [15, 62] and 73 [19, 95] days in the COVID negative and positive group, respectively (p=0.02). There was no significant difference in time from diagnosis to the first systemic treatment between the study groups.

In addition, although rate of early stage versus advanced stage disease was not statistically different between the study groups however the tumor size was slightly larger in the COVID positive group (3.4 cm [3.2, 9.3] vs. 3.1 cm [3, 9.1], p = 0.02).

Conclusion Surgical management and radiation therapy was delayed in COVID positive patient (time from diagnosis to initiation of treatment). Future studies are warranted to address the long-term cancer related outcomes.

Disclosures Authors have no conflict of interest to report.

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