Introduction/Background Lymphoepithelioma-like carcinoma (LELC) of the uterine cervix is a rare variant of squamous cell carcinoma. This tumor is characterized the presence of poorly differentiated epithelial cells surrounded by a prominent lymphocytic infiltration.

Methodology We describe two cases of LELC of the uterine cervix treated in our department of radiotherapy in Sousse in 2006 in 25 years

Results Case 1: Ms. AB aged 26, with no notable history, who presented with metrorrhagia. On clinical examination, there was a tumor invading the vagina to the lower third. On histopathological examination, it was a LELC of the uterine cervix. On imaging, we had a tumor process from the cervix extending to the vagina measuring 9 cm with pelvic lymphnodes. The patient had concomitant radiochemotherapy at a dose of 45 Gy (1.8Gy/fraction) to the pelvis with a boost up to 68.4 Gy to pelvic and inguinal involved lymphnodes. The patient was lost to follow-up after the end of treatment.

Case 2: Ms. AF, aged 63, with no notable history, had consulted for metrorrhagia with deterioration in general condition. She had an indurated cervix invading the vagina. The pelvic MRI showed a large tumor of the cervix infiltrating the uterus, the parameters and two thirds of the vagina with the presence of pelvic lymphadenopathy. Cervical biopsy showed LELC. The patient underwent concomitant radiochemotherapy at a dose of 45 Gy at a rate of 1.8 Gy/session with clinical and radiological improvement upon evaluation. She was proposed for curative surgery due to the good response. Furthermore, she was lost from follow-up for 2 years and then returned with a local recurrence of her disease.

Conclusion LELC appears to have a better outcome than the usual squamous cell carcinoma of the uterine cervix. Prospective data is needed to better understanding of the evolution and the prognosis of this rare entity.

Disclosures No.