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243 Association between SDF-1 G801A gene polymorphism and cervical cancer: evidence from a meta-analysis
  1. Ines Zidi1,
  2. Nadia Boujelbene2,
  3. Imen Ouzari1,
  4. Mohamed Ali Ayadi3 and
  5. Ines Zemni3
  1. 1Laboratory Microorganisms and Active Biomolecules, Sciences Faculty of Tunis, University Tunis El Manar, Tunis, Tunisia
  2. 2Department of Pathology, Salah Azaïz Institute, Faculty of Medicine, Tunis, Tunisia
  3. 3Department of Surgical Oncology, Salah Azaïz Institute, Faculty of Medicine, Tunis, Tunisia


Introduction/Background The association of stromal cell-derived factor-1 (SDF-1) gene polymorphism has attracted increasing interest in recent years. The SDF-1 G801A (rs 1801157) polymorphism involves the substitution of guanine with adenine at base pair 801 of the 3′-UTR of the SDF-1 gene. Our meta-analysis examined the association of the rs1801157 polymorphism with cervical cancer.

Methodology A case-control meta-analysis of three studies involving 714 cases and 1021 controls was performed to investigate the association between SDF-1 polymorphism and cervical cancer.

Results Pooled results indicate that the SDF-1 G allele and GG genotype reduce cervical susceptibility in randomized models (Allelic model: OR = 0.749, 95% CI = 0.584–0.960, p = 0.023); recessive model, GG versus GA+AA: OR = 0.791, 95% CI = 0.647–0.968, p = 0.023; and codominant model, GG versus AA: OR = 0.456, 95% CI = 0.213–0.977, p = 0.043). Heterogeneity was generally moderate. Egger and Begg’s p-values were not significant (two-tailed p-value > 0.05), indicating no sample size effect for all genetic models except for the dominant, and one codominant models. The funnel plot was symmetrical, indicating no publication bias.

Conclusion Although the number of studies is limited, our meta-analysis suggests that the SDF-1 G801A polymorphism may be associated with a reduced risk of cervical cancer. More studies are needed to further evaluate the role of the SDF-1 G801A polymorphism in the etiology of cervical cancer.

Disclosures The authors certify that there is no conflict of interest to declare.

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