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239 IL-1beta gene polymorphism is associated with cervical cancer: an updated meta-analysis
  1. Ines Zidi1,
  2. Ines Zemni2,
  3. Imen Ouzari1,
  4. Mohamed Ali Ayadi2 and
  5. Nadia Boujelbene3
  1. 1Laboratory Microorganisms and Active Biomolecules, Sciences Faculty of Tunis, University Tunis El Manar, Tunis, Tunisia
  2. 2Department of Surgical Oncology, Salah Azaïz Institute, Faculty of Medicine, Tunis, Tunisia
  3. 3Department of Pathology, Salah Azaïz Institute, Faculty of Medicine, Tunis, Tunisia


Introduction/Background Interleukin-1 beta (IL-1B) participates in many cellular processes, including inflammation, cell differentiation and proliferation. The IL-1B -511 A/G (rs 16944) gene polymorphism of the promoter region has been studied in cancer. Many studies have investigated the association between the IL-1B polymorphism and cervical cancer susceptibility. However, the results were controversial. Here, we pooled cases/controls in a meta-analysis to investigate the association of rs16944 with cervical risk (CC).

Methodology We searched published studies in Pubmed and Scopus databases. We meta-analyzed 7 studies (1415 cases and 1573 controls; 5 studies of Asian ethnicity; 3 studies performed with the same PCR-RFLP technique) to study the association between IL-1B gene polymorphism with CC in fixed and randomized models.

Results The overall results of the present meta-analysis demonstrated that there is no significant association between IL1-B polymorphism and CC susceptibility. However ethnicity-stratified meta-analysis showed a significant association between the IL-1B -511 A/G polymorphism and CC in Asians according to homozygous GG+AA vs. GA (OR = 0.849, 95% CI = 0.726–0.992, p = 0.039) fixed-model. After stratification by technique used, we revealed an association of IL-1B with CC under allelic G vs. A (OR = 0.787, 95% CI = 0.687–0.902, p = 0.001), recessive GG vs. GA+AA (OR = 0.581, 95% CI = 0.452–0.749, p = 0.000), codominant GG vs. AA (OR = 0.574, 95% CI = 0.423–0.781, p = 0.000), and codominant GG vs. GA (OR = 0.593, 95% CI =0.455–0.772, p = 0.000) fixed-models. Our results reveal that the minor G allele and the GG genotype may protect against CC. Heterogeneity was low to moderate. Egger and Begg’s p-values were generally not significant (two-tailed p-value > 0.05), indicating no sample size effect. There was no evidence of publication bias.

Conclusion Our results demonstrate that the IL-1B -511 A/G gene polymorphism is associated with CC.

Disclosures The authors certify that there is no conflict of interest to declare.

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