Introduction/Background Uterine cancer is the most common gynecologic malignancy in resource-abundant countries and is the second most common in resource-limited countries (cervical cancer is more common). The incidence of endometrial carcinoma (EC) is increasing in resource-abundant countries due to increased obesity and longer life expectancy.

The standard initial treatment of EC is hysterectomy, bilateral salpingo-oophorectomy, and assessment of retroperitoneal lymph nodes. This is an acceptable option for the majority of patients with EC, most of whom are postmenopausal. However, younger patients may desire fertility-sparing treatment options. For patients who are candidates for fertility preservation, the most common approach is progestin therapy and deferral of surgical staging until after completion of childbearing.

Methodology Preserving fertility is an achievable challenge in patients with low-grade disease confined to the uterus. This video demonstrates the follow-up of a patient diagnosed with Grade 1 endometrioid carcinoma on a polyp via hysteroscopy.

Results Through progestin treatment and close monitoring with hysteroscopic biopsies, we achieved stability and treatment response, enabling the patient to achieve spontaneous conception and maintain a normal pregnancy course as of the date of this communication.

Conclusion With this case, we aim to highlight the role of fertility preservation in oncological pathology, enabling selected patients, under close surveillance, to fulfill their desire for motherhood.

Disclosures .