Introduction/Background Many articles have been published evaluating the relationship between depression and cancer, with inconsistent results. The mechanism of the association between cancer and depressive mood disorder is presented in figure 1 based on the papers showing that depression are associated with worsening of cancer. However, most of the published studies have been conducted in colorectal, lung, and breast cancer patients, and few have been conducted in gynecological cancer patients. Hence, the aim of this study was to evaluate the relationship between depressed mood and gynecological cancer outcomes, identifying risk factors for cancer aggravation.

Methodology This study was a retrospective analysis of gynecological cancer patients (January 2020-August 2022) at Korea University Anam Hospital using Patient Health Questionnaire-9 (PHQ-9). Patients were classified into non-depressed mood (NDM) and depressed mood (DM) based scores. Statistical analysis was performed using Student’s t-test, chi-square test, Fisher’s exact test, Kaplan-Meier analysis, and Cox regression analyzing using SPSS.

Results Of the 217 participants, the NDM group comprised 129 patients, and the DM group comprised 88. The two-year disease-free survival (DFS) rates showed significant differences (NDM, 93.6%; DM 86.4%; p = 0.006), but overall survival (OS) did not (p = 0.128). Patients with stage 3 or higher cancer, undergoing five or more chemotherapies, experiencing post-chemotherapy side effects, and depressed mood had an increased risk of cancer aggravation.

Conclusion Appropriate treatment of depressed mood, as well as adequate treatment for advanced gynecological cancer patients, those with numerous chemotherapies, and those with post-chemotherapy side effects, may con-tribute to reducing the risk of cancer aggravation.

Disclosures None

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Abstract 295 Figure 1