Introduction/Background Vulvar cancer is the fourth most common type of gynecological cancer and encompasses approximately 6% of all female genital tract malignancies. Human papillomavirus (HPV)-associated tumors affect relatively young women and arise from high-grade intraepithelial lesions. HPV-independent tumors tend to affect older women and usually arise in a background of inflammatory skin disorders and a subtle variant of in situ lesion called differentiated vulvar intraepithelial neoplasia.

Methodology In our study, testing for HPV DNA by polymerase chain reaction was performed in 42 patients.

Results In young patients, highly oncogenic HPV genotypes were identified in 78% (16, 18, 31, 33), and the association with the tumor process in this group was 100%. HPV in women of peri- and postmenopausal age is represented by a diverse range of genotypes (6, 11, 16, 18, 31, 33), the relationship with the malignant process was 31%.

Conclusion HPV-induced vulvar neoplastic lesions seem to have a better outcome in terms of both disease-free survival and overall survival when compared with non-HPV-related lesions. The HPV status may act as a biomarker for predicting the prognosis of patients with vulvar cancer.

Disclosures No.