Introduction/Background Gynecological cancers, including cervical cancer, ovarian cancer, endometrial and vulva cancer are leading causes of cancer-related death in women worldwide. Habits and diet play an important role in cancer development, which is widely accepted. Vitamin D is a fat-soluble vitamin that plays an important role in cancer prevention by regulating cellular proliferation and metabolism. However, the impact of Vitamin D levels and gynecological cancers is poorly studied. The aim of this study was to describe the prevalence of Vit-D deficiency in gynecologic cancer patients in a Mediterranean area.

Methodology A retrospective descriptive observational study was conducted in a single institution. All consecutive new diagnoses of gynecologic cancer patients with available clinical data were included between January 2019 and December 2022. Patients were stratified according to Vitamin-D levels. Vitamin-D sufficiency was defined as a circulating concentration > 30–40 ng/ml, insufficiency when the concentration is 20–30 ng/ml and deficiency at < 20 ng/ml. The relationship between Vitamin D levels and gynecologic cancer was assessed.

Results A total of 239 patients were included: 46 cervical cancer, 18 vulva cancer, 117 endometrial cancer and 58 ovarian cancer. The prevalence of Vitamin D deficiency of gynecologic cancer patients was 60.3% (56.5% of cervical cancer, 50% of vulva cancer, 64.1% of endometrial cancer and 58.6% of ovarian cancer). Vitamin D deficiency was not associated with age (p=0.392), cancer localization (p=0.538), or cancer stage (p=0.347).

Conclusion These results suggest that a higher number of patients with gynecologic cancer presented Vitamin D deficiency. However, more studies are needed to validate our results and the implications of Vitamin D deficiency in gynecological cancer patients.

Disclosures No disclousures.