Introduction/Background The diagnosis and treatment of gynecological cancer, including surgical procedures,chemotherapy, and pelvic radiotherapy, impact on women’s quality of life (QoL) leaving them at risk of fatigue, anxiety and depression.

The aim of this study was to assess fatigue, anxiety and depression levels in patients receiving Volumetric Modulated Arc Therapy (VMAT) for gynecological cancer.

Methodology This observational study was conducted among gynecological cancer patients treated with VMAT. An interview was conducted utilizing two validated questionnaires: the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTCQLQ-C30) and its Fatigue Module (EORTC QLQ-FA12) for evaluation the QoL and fatigue, and the hospital anxiety and depression scale (HADS) for assessment of anxiety and depression.

Results A total of 50 patients (31 with endometrial cancer, 17 with cervical cancer and 2 with vulvar cancer) were interviewed after a median follow up of 3 months. The median age was 57 years. Thirty-six patients (72%) received concomitant chemotherapy. Forty-eight percent of patients reported high QoL. The emotional fatigue was the most pronounced symptom with a median score of 36.77.

A low score of emotional fatigue was correlated with higher QoL p=0.001. The median scores of physical and cognitive fatigue were 33.24 and 30.52, respectively. Thirty-five percent of study participants had abnormal scores on the anxiety subscale and 32,5% on the depression subscale. The median scores of anxiety and depression were respectively 5.9[0–11] and 6.1[0–11]. Participants with high scores of emotional fatigue had significantly more anxiety (p<0.003) and depressive symptoms (p <0.002).

Conclusion Emotional fatigue was the main predictor of anxiety disorders and depression, and contributed significantly to an impaired QoL.

Patient caregivers should pay more attention to psychological support and patient education to improve their quality of life.

Disclosures No disclosures.