Introduction/Background Vitamin D is involved in many regulatory processes in the body, especially in calcium and phosphate metabolism. In recent years, attention has been paid to the influence of vitamin D on the functioning of the immune system. Research shows a relationship between vitamin D levels and the risk of cancer development. The protective and antitumorigenic activities of vitamin D in the etiopathogenesis of ovarian cancer have also been demonstrated. Vitamin D deficiency in the population, including the Polish population, is common, and average concentrations are around 20 to 28 ng/ml.

Methodology A retrospective cohort-bases study on vitamin D levels among patients hospitalized at the Department of Gynecology, Obstetrics and Gynecological Oncology in Katowice Ligota, Poland between March 2021 and September 2023 was performed. 686 patients operated due to malignancies and benign lesions were induced in the analysis. Women operated for gynecological cancers constituted the study group (n=492). All other with benign lesions (n=194) were controls.

Results Patients with confirmed cancer had significantly lower vitamin D concentrations compared to the control group (27.0 vs. 29.2 ng/ml). In oncological patients, the lowest vitamin D concentration was found in patients with ovarian cancer (26.6 ng/ml), then with endometrial cancer and cervical cancer - 27.5 ng/ml and 27.9, respectively, p<0.05. We did not demonstrate a relationship between vitamin D concentration and the occurrence of severe postoperative complications, including death.

Conclusion The appropriate concentration of vitamin D may play a role in the prevention of gynecological cancers, including ovarian cancer. Vitamin D concentration appears to have no effect on the prevalence of postoperative complications.

Disclosures None