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1146 Morphological forms of the spread of atypical epithelium on the vaginal walls and vaults against congenital transformation zone background
  1. Anna Svintsitska1,2,
  2. Nataliya Lygyrda1,2 and
  3. Valentyn Svintsitskyi1,2
  1. 1National Cancer Institute, Kyiv, Ukraine
  2. 2Medical Centre of Colposcopy, Kyiv, Ukraine


Introduction/Background The danger of the congenital transformation zone (CTZ) of the cervix is the possibility of spreading epithelial lesions on the vaginal walls and vaults. The number and grade of epithelial lesions were calculated among patients with a CTZ observed in the Medical Centre of Colposcopy (Kyiv, Ukraine).

Knowledge about the histological form of the epithelium extending on the vaginal walls and vaults is fundamental to decision-making about the management of a clinical situation. In the case of a CTZ, the histological result is achieved by taking a targeted multifocal biopsy from different distance areas.

Methodology Histological results of the targeted multifocal biopsy of the cervix, vaginal walls, and vaults; immunohistochemical studies for HSIL (CIN 2–3) with the purpose of determination of morphological forms (normal and abnormal) and their frequency among patients with CTZ.

Results 142 patients with CTZ who had targeted multifocal biopsy of the cervix, vaginal walls and vaults took part in the study. The calculation of histological findings indicated the following data. Squamous cell metaplasia was found in 23 patients (16.2%). Vaginal adenosis was found in 7 patients (4.93%). Parakeratosis, hyperkeratosis was found in 31 patients (21.83%). LSIL is the most common morphological form in the group, it was obtained in 62 patients (43.66%). The number of patients with HSIL is also significant – 19 people (13.38%).

Conclusion Patient‘s management will be. Treatment measures are applied only to patients with established morphological verification and depending on the grade of lesions.

Disclosures No disclosures.

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