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570 Correlation between histological findings after targeted biopsy and post-LLETZ specimens in patients with cervical precancerous lesions
  1. Yavor Dimitrov Kornovski1,
  2. Yonka Ivanova Ivanova1,
  3. Stoyan Georgiev Kostov1,2,
  4. Stanislav Hristov Slavchev1,
  5. Dimitar Metodiev Mitkov3,4 and
  6. Angel Danchev Yordanov5
  1. 1Department of Gynecology, Hospital ‘Saint Anna’, Medical University—’Prof. Dr. Paraskev Stoyanov’, 9002 Varna, Bulgaria, Varna, Bulgaria
  2. 2Research Institute, Medical University Pleven, 5800 Pleven, Bulgaria, Pleven, Bulgaria
  3. 3Clinical Pathology Laboratory, MHAT ‘Nadezda’ Women’s Health Hospital, 1373 Sofia, Bulgaria, Sofia, Bulgaria
  4. 4Neuropathological Laboratory, University Hospital ‘Saint Ivan Rilski’, 1431 Sofia, Bulgaria, Varna, Bulgaria
  5. 5Department of Gynecologic Oncology, Medical University Pleven, 5800 Pleven, Bulgaria, Pleven, Bulgaria


Introduction/Background Low (LSIL) and high (HSIL) squamous intraepithelial lesions are precancerous lesions of the uterine cervix with unknown frequency. The aim of this study is to investigate the correlation between histological findings after loop electrosurgical excision (LLETZ) and biopsy regarding LSIL, HSIL and to calculate the sensitivity (negative predictive value – NPV) and specificity (positive predictive value – PPV) of the histological biopsy result regarding HSIL in the final histological result after LLETZ.

Methodology Prospective study (01.01.2017 - 31.07.2021) including 189 patients with cervical precancerous lesions treated by the LLETZ procedure in outpatient settings.

One gynecologic oncologist performed the biopsies and LLETZ procedures and one histopathologist diagnosed histological specimens from the biopsy and LLETZ. The LLETZ was performed with different-sized loops and a SURTRON device with cutting and coagulation modes, and cutting and coagulation of 100 and 60 W powers, respectively.

The data were entered and processed with the IBM SPSS Statistics 25.0 statistical package and MedCalc Version 19.6.3. The significance level at which the null hypothesis was rejected was set at p<0.05. The statistical methods used to assess correlation, sensitivity, specificity, positive and negative predictive values were Fisher-Freeman-Halton exact test p<0.001 and Cramer’s test).

Results Correlation analysis between the histological result after LLETZ procedure and the histological result of targeted biopsy showed a significant correlation between the histological findings; there was a strong correlation with a Cramer’s contingency coefficient of 0.728.

The sensitivity and negative predictive value of the targeted biopsy with respect to HSIL in the final histological result after LLETZ were high (89 and 81%, respectively), whereas the specificity and positive predictive value were lower (61 and 75%, respectively).

Conclusion The histological result of targeted biopsy had higher sensitivity and lower specificity with respect to HSIL in the histological result after LLETZ.

Disclosures Authors certify they have nothing to disclose.

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