Introduction/Background Human papillomavirus (HPV) infection, a prevalent sexually transmitted infection globally, is linked to cervical lesion development with reduced clearance rates as age increases. Currently, no established clinical approach exists for the combined treatment of couples. In this clinical case, a combined treatment involving a Coriolus versicolor-based vaginal gel for her and a Reishi-based food supplement for him was used for HPV-clearance and cytology normalization.

Methodology This case features an asymptomatic 54-year-old woman, who attended a follow-up because her partner presented genital lesions. In physical examination, normal external genitals and speculoscopy showing slight cervical erosion were found.

Relevant tests were performed HPV test, cytology, colposcopy, and biopsy. The results obtained were positive to HPV 26, 53 and 66 (high risk (HR)-HPV), atypical squamous cells of undetermined significance (ASCUS), focal Lugol’s at 6h negative lesion, and acute moderate cervicitis with reactive inflammatory changes which could not discard the presence of dysplasia, respectively. Therefore, a conservative treatment with a Coriolus versicolor-based vaginal gel was prescribed (1 cannula/day for 1 month + 1 cannula/alternate days for 5 months). Additionally, her partner was treated with a Reishi-based food supplement (1 capsule daily for 6 months).

Results After 3 months of treatment, the patient returned to the clinic for testing. Cytology and speculoscopy showed normalization and clearance of HR-HPV types was confirmed. However, the patient now tested positive for low-risk HPV types 62 and 81. The patient continued the treatment with the vaginal gel and her partner with the Reishi-based food supplement for up to 6 months.

Conclusion This clinical case shows the effectiveness of a combined treatment involving the use of a Coriolus versicolor-based vaginal gel for a 54-year-old patient and a Reishi-based food supplement for her partner, in the repair of HPV-related cervical lesions and the clearance of HR-HPV after only 3 months.

Disclosures .