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952 A conservative treatment of CIN 2 using a coriolus versicolor-based vaginal gel: an observational study
  1. Nadia Nassar Melic,
  2. Miguel Díaz Vega,
  3. Silvia Herrero Barrios,
  4. Gemma Pardina Claver and
  5. Marta Padin Fabeiro
  1. Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain

Abstract

Introduction/Background According to the American Society of Colposcopy and Cervical Pathology (ASCCP), 50% of CIN 2 cases managed conservatively spontaneously regress. The aim of this study was to evaluate the effect of a Coriolus versicolor-based vaginal gel in the conservative management of CIN 2 lesions.

Methodology A retrospective and prospective cohort, single-center, observational study, including women aged ≥18 years with a diagnosis of CIN 2. Inclusion criteria aligned with the Spanish Society of Colposcopy and Cervical Pathology (AEPCC) guidelines for CIN 2 conservative treatment, requiring visible transition zone in colposcopy images, lesions affecting less than 2 quadrants, non-affected endocervix, and accepting cytology/colposcopy after 6 months. The retrospective cohort, spanning 2010 to 2017, assessed the regression, persistence, and progression of HPV-dependent lesions in women with CIN 2 undergoing conservative management. Conversely, women in the prospective cohort received treatment with a Coriolus versicolor-based vaginal gel—1 cannula/day for the first month, followed by 1 cannula every other day for the subsequent 5 months. Baseline and 6-month biopsies were performed for evaluation.

Results In the retrospective cohort, 117 women (average age: 35.91) were included, while the prospective cohort included 44 women (average age: 36.09). Three patients from the prospective cohort were excluded due to the absence of a biopsy after 6 months. Following a 6-month treatment, 68.2% in the treated group showed regression, 11.4% persisted in CIN 2, and 18.2% progressed to CIN 3. In the retrospective cohort, 55% regressed, 13% persisted, and 32% progressed. However, non statistically significant differences were observed.

Conclusion The Coriolus versicolor-based vaginal gel 6-month treatment seems to increase the regression of the lesions compared to spontaneous resolution and could represent a clinical advantage compared to the ‘wait and see’ approach in patients meeting the conservative treatment criteria for CIN 2 lesions.

Disclosures .

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