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839 The impact of surgery in metastatic breast cancer (about 150 cases)
  1. Haiat Midyani,
  2. Youssef Imami,
  3. Mohamed Mrida,
  4. Younes Bencherifi,
  5. Mohamed Ennachit,
  6. Mustapha Benhassou and
  7. Mohamed El Karroumi
  1. Ibn Rochd University Hospital, Casablanca, Morocco

Abstract

Introduction/Background Metastatic breast cancer is an incurable disease. Medical treatments are considered palliative with the objectives of extending survival, controlling tumor burden and maintaining quality of life. Surgical excision of the initial tumor site in cases of immediately metastatic cancer has been described for many other primary cancers (kidney, colorectal cancer...), and a benefit in terms of survival has been demonstrated in several studies.

Methodology This is a cross-sectional study; descriptive and analytical study on 150 patients with metastatic breast cancer from the outset and treated within the Radiotherapy-Oncology departments and the Mohamed VI center (CMVI) for the treatment of cancers at the Ibn Rochd University Hospital in Casablanca (Morocco) on a period of 3 years.

Results The average age of our patients was 50.7 years.

On the paraclinical level: The stellar image on mammography represented 69.33%.

On the anatomopathological level: Infiltrating ductal cancer is the predominant histological type with 94.66% of cases.

Histoprognostic grade (SBR) II is the most common with 45.33%. HR was positive in 58.67% and luminal B was the most common.

Therapeutically Neoadjuvant chemotherapy was administered in 123 patients or 82%, surgery 43.33% of cases associated with chemotherapy, adjuvant radiotherapy with hormonal therapy and targeted therapy.

Multivariate analysis of survival after adjustment for other confounding factors showed an overall survival three times higher in operated patients compared to non-operated patients (p<0.001).

Conclusion Metastatic breast cancer is a heterogeneous group of poor prognosis tumors with different clinical presentation and variable biological aggressiveness which gives them a different prognosis.

The role of surgical treatment of the primary tumor is demonstrated retrospectively with numerous selection biases.

Disclosures No declaration of interest.

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